Mouth ulcers are currently treated with medications that distribute the medicine over the entire mouth. Consequently, medications may be ineffective as they only offer short contact times between drug and lesion. Moreover, not much of the medication actually touches the ulcer, with the rest dissipating to other areas of the mouth.
Mouth Ulcers: Causes
The exact cause of mouth ulcers is still not known and varies from person-to-person. Still, there are some common causes and several factors that may aggravate mouth ulcers, including the following:
- quitting smoking
- citrus fruits like pineapples and oranges, and other foods high in acidity or spice
- braces, poor-fitting dentures, and other apparatus that may rub against the mouth and gums
- stress or anxiety
- hormonal changes during pregnancy, puberty, and menopause
- medications including beta-blockers and pain killers
- genetic factors
Some people may develop ulcers as a result of a different medical condition or a nutritional deficiency.
Conditions such as Crohn’s disease, vitamin B12 deficiency, or a weakened immune system may all trigger ulcers to form.
Mouth Ulcers: New Self-Adhesive Drug Patch Is Here
There is now good news for mouth ulcer sufferers. Researchers at the University of Sheffield, UK and the Danish company Dermtreat, have jointly developed an innovative patch, known as the Rivelin, that improves treatment for mouth ulcers.
The patch provides direct-targeted treatment to ulcers with steroids and other drugs. The patch also has a protective barrier around the affected area to prevent the medicine from leaking away.
Mouth Ulcers: The Drug Patch Manufacturing Process
The Rivelin drug patches are manufactured with a technique called electrospinning. Ultra-fine bio-compatible fibers are spun into patches containing two layers. The outer layer is liquid resistant and prevents non-medicine liquid getting in and liquid treatment getting out. The treatment drug is loaded onto the inner layer and treats the ulcer.
Mouth Ulcers: Patient Feedback Self Adhesive Rivelin Patch
In a patient survey, patients noted that the patch was comfortable to wear and its adhesion lasted a long time. There were no reports of any after taste or irritation.
Currently, the patch is in Phase II clinical trials in both the United States and Britain.