Brushing your teeth daily could prevent the onset of Alzheimer’s disease. Sounds like a bad joke, but it’s not. In fact, serious research is currently ongoing by researchers who have determined that gum disease (gingivitis) could determine if you do or don’t get Alzheimer’s.
This drug research company is called Cortexyme and is located in San Francisco, CA.
Cortexyme is targeting a specific pathogen found in the brain of Alzheimer’s patients that causes cell destruction and other pathology in animal models. This pathogen originates in the mouth from bacteria that causes gingivitis. This bacteria can move from the mouth to the brain where it produces a protein that destroys nerve cells responsible for learning, memory, and cognitive tasks. The end result is Alzheimer’s disease.
Brushing your teeth and flossing every day destroys this bacteria. The researchers examined 53 persons with Alzheimer´s and discovered the enzyme in 96 per cent of the cases. According to Mydel, this knowledge gives researchers a possible new approach for attacking Alzheimer´s disease.
Cortexyme has developed a small molecule, COR388, that destroys this bacteria. At this time, it has passed through preclinical trials and Phase Ib testing — and is currently in the Phase 2-3 testing period.
The participants are Alzheimer’s patients who are in the mild to moderate stages of the disease.
COR388 reduces and destroys the bacteria caused by gingivitis and periodontal disease. It protects neurons located in the hippocampus area of the brain. This organ is responsible for short and long term memory and cognitive ability. It is the first brain area attacked by Alzheimer’s disease.
Brushing Your Teeth: Facts About Gingivitis
- The bacteria Porphyromonas gingivalis (P. gingivalis) is one of the main causes to infection in the gums.
- This bacteria causes chronic infection in the gums, but can move to the brain where it can damage nerve cells in the brain.
- Also. 50 per cent of the population has this bacteria in one or another form.
- Another 10 per cent that have this bacteria will develop serious gum disease, loose teeth, and have an increased risk of developing Alzheimer´s disease.
- In addition to Alzheimers, this bacteria links to rheumatism, COPD and esophageal cancer.